diff --git a/lib/modules/manager/setup-cfg/__fixtures__/setup-cfg-1.txt b/lib/modules/manager/setup-cfg/__fixtures__/setup-cfg-1.txt
index 9eb2f867909aa2997c08cff924b934e80f46930f..1fb0cbd0328acdcedf793f94f77d90134db11120 100644
--- a/lib/modules/manager/setup-cfg/__fixtures__/setup-cfg-1.txt
+++ b/lib/modules/manager/setup-cfg/__fixtures__/setup-cfg-1.txt
@@ -17,6 +17,8 @@ install_requires =
 
     requests[security] ~=2.18
     compact~=1.2.3;python>'3.10'
+install_requires= 
+    responses >=2.27.0
 
 setup_requires =
     six ~=1.4
diff --git a/lib/modules/manager/setup-cfg/__snapshots__/extract.spec.ts.snap b/lib/modules/manager/setup-cfg/__snapshots__/extract.spec.ts.snap
index 453adf55dcd22301f30bb8d764581e2e27f6aa4f..bef317998567c0a96db850f487cfd83987c2cf90 100644
--- a/lib/modules/manager/setup-cfg/__snapshots__/extract.spec.ts.snap
+++ b/lib/modules/manager/setup-cfg/__snapshots__/extract.spec.ts.snap
@@ -83,6 +83,12 @@ exports[`modules/manager/setup-cfg/extract extractPackageFile() extracts depende
       "depName": "compact",
       "depType": "install",
     },
+    {
+      "currentValue": ">=2.27.0",
+      "datasource": "pypi",
+      "depName": "responses",
+      "depType": "install",
+    },
     {
       "currentValue": "~=1.4",
       "datasource": "pypi",
diff --git a/lib/modules/manager/setup-cfg/extract.spec.ts b/lib/modules/manager/setup-cfg/extract.spec.ts
index c369d0759559855e851b8f47002396cf9077d3c7..efa02d5cc1fb70e219f19f9fcd3e0dadae4c5312 100644
--- a/lib/modules/manager/setup-cfg/extract.spec.ts
+++ b/lib/modules/manager/setup-cfg/extract.spec.ts
@@ -24,6 +24,7 @@ describe('modules/manager/setup-cfg/extract', () => {
           { depName: 'nmspc.pkg', currentValue: '==1.0' },
           { depName: 'requests', currentValue: '~=2.18' },
           { depName: 'compact', currentValue: '~=1.2.3' },
+          { depName: 'responses', currentValue: '>=2.27.0' },
           { depName: 'six', currentValue: '~=1.4' },
           { depName: 'tqdm', currentValue: '~=4.19' },
           { depName: 'tenacity', currentValue: '~=6.0' },
diff --git a/lib/modules/manager/setup-cfg/extract.ts b/lib/modules/manager/setup-cfg/extract.ts
index f006ef70ba6378b3e4338536e5ea9814bf535bf5..1b73ebb63c22daa0ed8e09378cda90e1780250e4 100644
--- a/lib/modules/manager/setup-cfg/extract.ts
+++ b/lib/modules/manager/setup-cfg/extract.ts
@@ -11,7 +11,7 @@ function getSectionName(str: string): string {
 }
 
 function getSectionRecord(str: string): string {
-  const [, sectionRecord] = regEx(/^([^\s]+)\s+=/).exec(str) ?? [];
+  const [, sectionRecord] = regEx(/^([^\s]+)\s*=/).exec(str) ?? [];
   return sectionRecord;
 }