diff --git a/lib/manager/gradle/__fixtures__/build.gradle.example1 b/lib/manager/gradle/__fixtures__/build.gradle.example1
index e4a2854e79ce1a2d2b265eb0e0c34b490c85f363..5ba8e6206b6960210644c27a8199e7d845e13749 100644
--- a/lib/manager/gradle/__fixtures__/build.gradle.example1
+++ b/lib/manager/gradle/__fixtures__/build.gradle.example1
@@ -14,6 +14,7 @@ buildscript {
         classpath 'com.github.jengelman.gradle.plugins:shadow:1.2.3'
         classpath 'com.fkorotkov:gradle-libraries-plugin:0.1'
         classpath "gradle.plugin.se.patrikerdes:gradle-use-latest-versions-plugin:0.2.3"
+        classpath 'org.apache.openjpa:openjpa:3.1.1'
     }
 }
 
@@ -73,6 +74,8 @@ dependencies {
     // optional dependencies for using Spock
     testCompile "org.hamcrest:hamcrest-core:1.3" // only necessary if Hamcrest matchers are used
     testRuntime "cglib:cglib-nodep:3.1" // allows mocking of classes (in addition to interfaces)
+
+    dependency 'org.apache.openjpa:openjpa:3.1.1'
 }
 
 task integration(type: Test) {
diff --git a/lib/manager/gradle/__snapshots__/index.spec.ts.snap b/lib/manager/gradle/__snapshots__/index.spec.ts.snap
index e9758e7b91d23b46099f6e14f739671efec556a9..aaeec7a9edb9ad03e6455d7314341c9ec1e7f2a1 100644
--- a/lib/manager/gradle/__snapshots__/index.spec.ts.snap
+++ b/lib/manager/gradle/__snapshots__/index.spec.ts.snap
@@ -814,3 +814,5 @@ exports[`manager/gradle/index updateDependency should update an existing module
 exports[`manager/gradle/index updateDependency should update an existing plugin dependency 1`] = `Array []`;
 
 exports[`manager/gradle/index updateDependency should update an existing plugin dependency with Kotlin DSL 1`] = `Array []`;
+
+exports[`manager/gradle/index updateDependency should update dependencies in same file 1`] = `Array []`;
diff --git a/lib/manager/gradle/build-gradle.ts b/lib/manager/gradle/build-gradle.ts
index 84ca91c2d4b2b55f3fb884fc99c17bf063007fa7..8ab31dd1074b74ad7ff7af762a1352a60b33cea6 100644
--- a/lib/manager/gradle/build-gradle.ts
+++ b/lib/manager/gradle/build-gradle.ts
@@ -48,6 +48,14 @@ function kotlinPluginStringVersionFormatMatch(
   return regEx(`(id\\("${dependency.group}"\\)\\s+version\\s+")[^$].*?(")`);
 }
 
+function dependencyStringVersionFormatMatch(
+  dependency: GradleDependency
+): RegExp {
+  return regEx(
+    `(dependency\\s+['"]${dependency.group}:${dependency.name}:)[^'"]+(['"])`
+  );
+}
+
 function allMapFormatOrders(
   group: string,
   name: string,
@@ -202,19 +210,18 @@ function updateVersionLiterals(
     moduleStringVersionFormatMatch(dependency),
     groovyPluginStringVersionFormatMatch(dependency),
     kotlinPluginStringVersionFormatMatch(dependency),
+    dependencyStringVersionFormatMatch(dependency),
     ...moduleMapVersionFormatMatch(dependency),
     ...moduleKotlinNamedArgumentVersionFormatMatch(dependency),
   ];
+  let result = buildGradleContent;
   for (const regex of regexes) {
-    const match = regex.exec(buildGradleContent);
+    const match = regex.exec(result);
     if (match) {
-      return buildGradleContent.replace(
-        match[0],
-        `${match[1]}${newVersion}${match[2]}`
-      );
+      result = result.replace(match[0], `${match[1]}${newVersion}${match[2]}`);
     }
   }
-  return null;
+  return result === buildGradleContent ? null : result;
 }
 
 function updateLocalVariables(
diff --git a/lib/manager/gradle/index.spec.ts b/lib/manager/gradle/index.spec.ts
index a3cc67e177eaa9dc4d36592b0061c69c4a08444e..9c28b9c1fbac8703b43ec52c8232672374c8eb5f 100644
--- a/lib/manager/gradle/index.spec.ts
+++ b/lib/manager/gradle/index.spec.ts
@@ -389,6 +389,47 @@ describe(getName(__filename), () => {
 
       expect(execSnapshots).toMatchSnapshot();
     });
+
+    it('should update dependencies in same file', async () => {
+      const execSnapshots = mockExecAll(exec, gradleOutput);
+
+      const buildGradleContent = await fsExtra.readFile(
+        `${fixtures}/build.gradle.example1`,
+        'utf8'
+      );
+
+      const upgrade = {
+        depGroup: 'org.apache.openjpa',
+        name: 'openjpa',
+        version: '3.1.1',
+        newValue: '3.1.2',
+      };
+
+      const buildGradleContentUpdated = manager.updateDependency({
+        fileContent: buildGradleContent,
+        upgrade,
+      });
+
+      expect(buildGradleContent).not.toContain(
+        'org.apache.openjpa:openjpa:3.1.2'
+      );
+
+      expect(buildGradleContentUpdated).not.toContain(
+        "dependency 'org.apache.openjpa:openjpa:3.1.1'"
+      );
+      expect(buildGradleContentUpdated).not.toContain(
+        "dependency 'org.apache.openjpa:openjpa:3.1.1'"
+      );
+
+      expect(buildGradleContentUpdated).toContain(
+        "classpath 'org.apache.openjpa:openjpa:3.1.2'"
+      );
+      expect(buildGradleContentUpdated).toContain(
+        "classpath 'org.apache.openjpa:openjpa:3.1.2'"
+      );
+
+      expect(execSnapshots).toMatchSnapshot();
+    });
   });
 
   ifSystemSupportsGradle(6).describe('executeGradle integration', () => {